Research Interests

Summary

Over close to last two decades, Bikramjit Basu has made outstanding contributions first to the field of Engineering Ceramics and lately to Biomaterials. His contributions in Engineering Ceramics exemplify his rationale and intelligent approaches to enhance the fracture resistance of structural ceramics through manipulation of microstructure at multiple length scales, while using superfast densification route (i.e. spark plasma sintering, SPS). With the help of experimental and computational analysis, Prof. Basu’s research has demonstrated how to establish a critical window in process parameter-composition (sinter-aid) space using self-patented multi-stage SPS route to develop difficult-to-sinter non-oxide ceramics with exceptional and reliable toughness properties [e.g. WC-ZrO2 (~10 MPa.m1/2)]. While explaining the origin of toughness enhancement, he has proposed guidelines to design microstructures to incorporate synergistic toughening mechanisms and has utilized the fracture mechanics approaches to correlate experimental measurements with theoretical predictions. In the field of Biomaterials, he has brought in a strong materials engineering perspective to address biologically and clinically relevant problems. In a set of unique experiments, he has illustrated that the internalized gold nanoparticles can guide the stem cell differentiation towards neurogenic or cardiomyogenic lineage on electroactive substrates, when direct or pulse electric stimuli is delivered respectively, in vitro. Using extensive experimental framework involving various cell lines (osteoblast, fibroblast, myoblast, schwann, neuroblastoma, stem cells) and biomaterial substrates (elastically compliant/stiff, electroactive/magnetoactive), he has developed an understanding of complex synergistic interaction among electrical conductivity/magnetization properties of biomaterials and stimulation parameters towards cell fate processes, in vitro. While addressing prosthetic infection, he conceptualized the use of ultrasmall gold nanoparticles (< 10 nm) as well as the use of periodic delivery of static or pulse magnetic field towards bactericidal property on magnetoresponsive biomaterial substrates, in vitro.

Research Interests

  • External field stimulated cell functionality on implantable biomaterials
  • Additive manufacturing (three dimensional printing) of porous scaffolds
  • Synthesis of biodegradable polymers for drug delivery and soft tissue regeneration
  • Multifunctional biomaterials for bone tissue engineering applications

Bikramjit Basu, PhD FNAE FNASc FWAST FBAO
Professor, Materials Research Centre,
Principal Investigator, Center for Excellence on Biomaterials for Orthopedic and Dental Applications
Indian Institute of Science,
Karnataka, India
Email: bikram@mrc.iisc.ernet.in,
Tel.: +91 80 2293 3256
Fax: +91 80 2360 7316

Other Affiliations:
Associate Faculty, Bio-Engineering Program,IISc, Bangalore
Honorary Distinguished Visiting Professor, Indian Institute of Engineering Science and Technology, Sibpur, Howrah